Synthesis and mechanical properties of conductive composite polylactic acid/polyaniline scaffold for potential tissue engineering

This thesis reports a new composite scaffold material that is conductive and porous made from degradable polylactic acid (PLA) and conducting polyaniline (PANI) which has the potential for use in promoting tissue regeneration. The conductive scaffold was successfully prepared using a simple yet effe...

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Main Author: Dahli, Farah Nuruljannah
Format: Thesis
Language:English
Published: 2016
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Online Access:http://eprints.utm.my/id/eprint/80970/1/FarahNuruljannahDahliMFChE2016.pdf
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spelling my-utm-ep.809702019-07-24T00:13:34Z Synthesis and mechanical properties of conductive composite polylactic acid/polyaniline scaffold for potential tissue engineering 2016-12 Dahli, Farah Nuruljannah TP Chemical technology This thesis reports a new composite scaffold material that is conductive and porous made from degradable polylactic acid (PLA) and conducting polyaniline (PANI) which has the potential for use in promoting tissue regeneration. The conductive scaffold was successfully prepared using a simple yet effective method known as freeze extraction method. The doped PANI was synthesised using conventional method of oxidative chemical polymerization. The electrical percolation state was successfully obtained at 3 wt% of PANI inclusion and reached at useable conductivity level for tissue engineering application at 4 wt% PANI, 2.91 x 10-3 Scm-1. 4 wt% inclusion of PANI was justified as the best PLA/PANI composite scaffold because it met the criterion as an electro-responsive material where the conductivity achieved was higher than 10-3 Scm-1. It is also much suitable material in the regeneration of skin tissue (fibroblast) because the mean pore size achieved was at 35.82 µm and optimum tensile strength at 3.08 MPa. The UV-spectrum of the conductive scaffold displayed transition peaks of PANI indicating the PANI was still in its conducting doped state inside the scaffold. Incubation for 24 weeks for in-vitro degradation revealed that the PANI component delayed the degradation of PLA. Preliminary bioactivity test results indicated that the doping agent able to form chelate at the scaffold surface and this could assist in the formation of in-vitro apatite during the biomimetic immersion. 2016-12 Thesis http://eprints.utm.my/id/eprint/80970/ http://eprints.utm.my/id/eprint/80970/1/FarahNuruljannahDahliMFChE2016.pdf application/pdf en public http://dms.library.utm.my:8080/vital/access/manager/Repository/vital:120268 masters Universiti Teknologi Malaysia, Faculty of Chemical and Energy Engineering Faculty of Chemical and Energy Engineering
institution Universiti Teknologi Malaysia
collection UTM Institutional Repository
language English
topic TP Chemical technology
spellingShingle TP Chemical technology
Dahli, Farah Nuruljannah
Synthesis and mechanical properties of conductive composite polylactic acid/polyaniline scaffold for potential tissue engineering
description This thesis reports a new composite scaffold material that is conductive and porous made from degradable polylactic acid (PLA) and conducting polyaniline (PANI) which has the potential for use in promoting tissue regeneration. The conductive scaffold was successfully prepared using a simple yet effective method known as freeze extraction method. The doped PANI was synthesised using conventional method of oxidative chemical polymerization. The electrical percolation state was successfully obtained at 3 wt% of PANI inclusion and reached at useable conductivity level for tissue engineering application at 4 wt% PANI, 2.91 x 10-3 Scm-1. 4 wt% inclusion of PANI was justified as the best PLA/PANI composite scaffold because it met the criterion as an electro-responsive material where the conductivity achieved was higher than 10-3 Scm-1. It is also much suitable material in the regeneration of skin tissue (fibroblast) because the mean pore size achieved was at 35.82 µm and optimum tensile strength at 3.08 MPa. The UV-spectrum of the conductive scaffold displayed transition peaks of PANI indicating the PANI was still in its conducting doped state inside the scaffold. Incubation for 24 weeks for in-vitro degradation revealed that the PANI component delayed the degradation of PLA. Preliminary bioactivity test results indicated that the doping agent able to form chelate at the scaffold surface and this could assist in the formation of in-vitro apatite during the biomimetic immersion.
format Thesis
qualification_level Master's degree
author Dahli, Farah Nuruljannah
author_facet Dahli, Farah Nuruljannah
author_sort Dahli, Farah Nuruljannah
title Synthesis and mechanical properties of conductive composite polylactic acid/polyaniline scaffold for potential tissue engineering
title_short Synthesis and mechanical properties of conductive composite polylactic acid/polyaniline scaffold for potential tissue engineering
title_full Synthesis and mechanical properties of conductive composite polylactic acid/polyaniline scaffold for potential tissue engineering
title_fullStr Synthesis and mechanical properties of conductive composite polylactic acid/polyaniline scaffold for potential tissue engineering
title_full_unstemmed Synthesis and mechanical properties of conductive composite polylactic acid/polyaniline scaffold for potential tissue engineering
title_sort synthesis and mechanical properties of conductive composite polylactic acid/polyaniline scaffold for potential tissue engineering
granting_institution Universiti Teknologi Malaysia, Faculty of Chemical and Energy Engineering
granting_department Faculty of Chemical and Energy Engineering
publishDate 2016
url http://eprints.utm.my/id/eprint/80970/1/FarahNuruljannahDahliMFChE2016.pdf
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