Surface entrapment of chitosan on 3d printed polylactic acid scaffold

This thesis reports a surface entrapment of chitosan on 3D printed PLA scaffold which has the potential use in promoting bone regeneration. The 3D scaffold was designed using SolidWorks and printed by Up Plus 3D printer and then incorporated with chitosan. The entrapped scaffold time was varied from...

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Main Author:	Zakaria, Nor Hidayah
Format:	Thesis
Language:	English
Published:	2018
Subjects:	TP Chemical technology
Online Access:	http://eprints.utm.my/id/eprint/81517/1/NorHidayahZakariaMFK2018.pdf
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spelling	my-utm-ep.815172019-08-23T05:21:15Z Surface entrapment of chitosan on 3d printed polylactic acid scaffold 2018 Zakaria, Nor Hidayah TP Chemical technology This thesis reports a surface entrapment of chitosan on 3D printed PLA scaffold which has the potential use in promoting bone regeneration. The 3D scaffold was designed using SolidWorks and printed by Up Plus 3D printer and then incorporated with chitosan. The entrapped scaffold time was varied from 5 to 90 s. The scaffold was characterized in respect of its mechanical and surface properties. Compressive test showed a higher compressive modulus properties in neat 3D printed PLA scaffolds and an optimum value of 22248 MPa at 15 s of chitosan immersion. The Fourier-transform infrared spectroscopy peak revealed an existence of biomacromolecule and new absorption peaks at 3357 and 1618 cm-1 compared to neat PLA on the scaffold while water contact angle showed an increase in hydrophilicity as entrapment time increased. The confocal laser scanning microscopy revealed the existence of entrapment areas approximately 8??m in depth. The scanning electron microscopy showed clearly 3D scaffold with high porosity, uniform distribution chitosan and a controlled and repetitive architecture on entrapped 3D printed scaffold. Immersion of neat and entrapped 3D printed PLA scaffold in simulated body fluid for 14 days resulted the formation of fully covered apatite layers on the surface of entrapped PLA scaffold whereas no change was observed in neat PLA scaffold. Overall, the mechanical and surface properties results showed the suitability of the combination of method and materials to develop 3D porous scaffold and their initial biocompatibility, both being valuable characteristic for tissue engineering applications. 2018 Thesis http://eprints.utm.my/id/eprint/81517/ http://eprints.utm.my/id/eprint/81517/1/NorHidayahZakariaMFK2018.pdf application/pdf en public http://dms.library.utm.my:8080/vital/access/manager/Repository/vital:122293 masters Universiti Teknologi Malaysia Chemical and Energy Engineering
institution	Universiti Teknologi Malaysia
collection	UTM Institutional Repository
language	English
topic	TP Chemical technology
spellingShingle	TP Chemical technology Zakaria, Nor Hidayah Surface entrapment of chitosan on 3d printed polylactic acid scaffold
description	This thesis reports a surface entrapment of chitosan on 3D printed PLA scaffold which has the potential use in promoting bone regeneration. The 3D scaffold was designed using SolidWorks and printed by Up Plus 3D printer and then incorporated with chitosan. The entrapped scaffold time was varied from 5 to 90 s. The scaffold was characterized in respect of its mechanical and surface properties. Compressive test showed a higher compressive modulus properties in neat 3D printed PLA scaffolds and an optimum value of 22248 MPa at 15 s of chitosan immersion. The Fourier-transform infrared spectroscopy peak revealed an existence of biomacromolecule and new absorption peaks at 3357 and 1618 cm-1 compared to neat PLA on the scaffold while water contact angle showed an increase in hydrophilicity as entrapment time increased. The confocal laser scanning microscopy revealed the existence of entrapment areas approximately 8??m in depth. The scanning electron microscopy showed clearly 3D scaffold with high porosity, uniform distribution chitosan and a controlled and repetitive architecture on entrapped 3D printed scaffold. Immersion of neat and entrapped 3D printed PLA scaffold in simulated body fluid for 14 days resulted the formation of fully covered apatite layers on the surface of entrapped PLA scaffold whereas no change was observed in neat PLA scaffold. Overall, the mechanical and surface properties results showed the suitability of the combination of method and materials to develop 3D porous scaffold and their initial biocompatibility, both being valuable characteristic for tissue engineering applications.
format	Thesis
qualification_level	Master's degree
author	Zakaria, Nor Hidayah
author_facet	Zakaria, Nor Hidayah
author_sort	Zakaria, Nor Hidayah
title	Surface entrapment of chitosan on 3d printed polylactic acid scaffold
title_short	Surface entrapment of chitosan on 3d printed polylactic acid scaffold
title_full	Surface entrapment of chitosan on 3d printed polylactic acid scaffold
title_fullStr	Surface entrapment of chitosan on 3d printed polylactic acid scaffold
title_full_unstemmed	Surface entrapment of chitosan on 3d printed polylactic acid scaffold
title_sort	surface entrapment of chitosan on 3d printed polylactic acid scaffold
granting_institution	Universiti Teknologi Malaysia
granting_department	Chemical and Energy Engineering
publishDate	2018
url	http://eprints.utm.my/id/eprint/81517/1/NorHidayahZakariaMFK2018.pdf
_version_	1747818349262274560

Surface entrapment of chitosan on 3d printed polylactic acid scaffold

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