Virgin coconut oil based nanostructured lipid carrier loaded with ficus deltoidea extract for skin barrier improvement

Ficus deltoidea (FD) is a medicinal herb which had been discovered to possess antioxidant and anti-inflammatory activities. Thus, it has the potential to be a good active ingredients for improving skin barrier function. Nanostructured lipid carrier (NLC) is a promising delivery system to transport F...

Full description

Saved in:

Bibliographic Details
Main Author:	Nadiha, Nor Azrini
Format:	Thesis
Language:	English
Published:	2018
Subjects:	Q Science (General)
Online Access:	http://eprints.utm.my/id/eprint/81527/1/NorAzriniNadihaMFChE2018.pdf
Tags:	Add Tag No Tags, Be the first to tag this record!

id	my-utm-ep.81527
record_format	uketd_dc
spelling	my-utm-ep.815272019-08-23T05:21:21Z Virgin coconut oil based nanostructured lipid carrier loaded with ficus deltoidea extract for skin barrier improvement 2018 Nadiha, Nor Azrini Q Science (General) Ficus deltoidea (FD) is a medicinal herb which had been discovered to possess antioxidant and anti-inflammatory activities. Thus, it has the potential to be a good active ingredients for improving skin barrier function. Nanostructured lipid carrier (NLC) is a promising delivery system to transport FD extract through the skin as it is composed of biocompatible lipids, which are similar to the intercellular part of the stratum corneum. The objective of this research is to formulate and characterize physicochemical and biological properties of virgin coconut oil (VCO) based NLC loaded with FD extract to improve skin barrier function. The FD loaded NLC (FDNLC) formulation was prepared using melt emulsification homogenization technique with glycerol monostearate as solid lipid, VCO as liquid lipid and combination of Tween 80 and soy lecithin as surfactant. The delivery system had the particle size of 158.033\|±\|10.53 nm, polydispersity index of 0.153\|±\|0.06, zeta potential of -42.32\|±\|1.54 mV, and encapsulation efficiency of 87.401\|±\|7.33%. Transmission electron microscopy images indicated that the prepared NLCs were spherical in shape with even size distribution. The formulation was stable for at least 40 days. Diffusion experiments showed that FDNLC diffused through the skin had the steady state flux of 12.727 mg/cm2.h, lag phase of 0.023 h, and permeability coefficient of 0.098 cm/h. The results showed better penetration in FDNLC compared to non-encapsulated FD. The skin test study in term of transepidermal water loss, hydration, elasticity, melanin and erythema showed significant improvement between week 0 and week 4 with the usage of cream loaded with FDNLC. Taken together, the formulation of FDNLC can be concluded to be efficient in improving skin barrier function. 2018 Thesis http://eprints.utm.my/id/eprint/81527/ http://eprints.utm.my/id/eprint/81527/1/NorAzriniNadihaMFChE2018.pdf application/pdf en public http://dms.library.utm.my:8080/vital/access/manager/Repository/vital:119784 masters Universiti Teknologi Malaysia Biosciences and Medical Engineering
institution	Universiti Teknologi Malaysia
collection	UTM Institutional Repository
language	English
topic	Q Science (General)
spellingShingle	Q Science (General) Nadiha, Nor Azrini Virgin coconut oil based nanostructured lipid carrier loaded with ficus deltoidea extract for skin barrier improvement
description	Ficus deltoidea (FD) is a medicinal herb which had been discovered to possess antioxidant and anti-inflammatory activities. Thus, it has the potential to be a good active ingredients for improving skin barrier function. Nanostructured lipid carrier (NLC) is a promising delivery system to transport FD extract through the skin as it is composed of biocompatible lipids, which are similar to the intercellular part of the stratum corneum. The objective of this research is to formulate and characterize physicochemical and biological properties of virgin coconut oil (VCO) based NLC loaded with FD extract to improve skin barrier function. The FD loaded NLC (FDNLC) formulation was prepared using melt emulsification homogenization technique with glycerol monostearate as solid lipid, VCO as liquid lipid and combination of Tween 80 and soy lecithin as surfactant. The delivery system had the particle size of 158.033\|±\|10.53 nm, polydispersity index of 0.153\|±\|0.06, zeta potential of -42.32\|±\|1.54 mV, and encapsulation efficiency of 87.401\|±\|7.33%. Transmission electron microscopy images indicated that the prepared NLCs were spherical in shape with even size distribution. The formulation was stable for at least 40 days. Diffusion experiments showed that FDNLC diffused through the skin had the steady state flux of 12.727 mg/cm2.h, lag phase of 0.023 h, and permeability coefficient of 0.098 cm/h. The results showed better penetration in FDNLC compared to non-encapsulated FD. The skin test study in term of transepidermal water loss, hydration, elasticity, melanin and erythema showed significant improvement between week 0 and week 4 with the usage of cream loaded with FDNLC. Taken together, the formulation of FDNLC can be concluded to be efficient in improving skin barrier function.
format	Thesis
qualification_level	Master's degree
author	Nadiha, Nor Azrini
author_facet	Nadiha, Nor Azrini
author_sort	Nadiha, Nor Azrini
title	Virgin coconut oil based nanostructured lipid carrier loaded with ficus deltoidea extract for skin barrier improvement
title_short	Virgin coconut oil based nanostructured lipid carrier loaded with ficus deltoidea extract for skin barrier improvement
title_full	Virgin coconut oil based nanostructured lipid carrier loaded with ficus deltoidea extract for skin barrier improvement
title_fullStr	Virgin coconut oil based nanostructured lipid carrier loaded with ficus deltoidea extract for skin barrier improvement
title_full_unstemmed	Virgin coconut oil based nanostructured lipid carrier loaded with ficus deltoidea extract for skin barrier improvement
title_sort	virgin coconut oil based nanostructured lipid carrier loaded with ficus deltoidea extract for skin barrier improvement
granting_institution	Universiti Teknologi Malaysia
granting_department	Biosciences and Medical Engineering
publishDate	2018
url	http://eprints.utm.my/id/eprint/81527/1/NorAzriniNadihaMFChE2018.pdf
_version_	1747818350981939200

Virgin coconut oil based nanostructured lipid carrier loaded with ficus deltoidea extract for skin barrier improvement

Similar Items