A novel electrospun nanofibrous composite membrane for chronic wound healing

In the present work an electrospun nanofibrous membrane composed of polyurethane (PU), sodium bicarbonate (NaHCO3) and pantothenic acid (PA) is developed for treating chronic wounds. Wounds are a common health problem and in particular, the chronic wounds such as vascular ulcers, diabetic ulcers and...

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Main Author:	Herrmann, Isabel
Format:	Thesis
Language:	English
Published:	2016
Subjects:	QC Physics
Online Access:	http://eprints.utm.my/id/eprint/85868/1/IsabelHerrmannMFBME2016.pdf
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spelling	my-utm-ep.858682020-07-30T07:35:22Z A novel electrospun nanofibrous composite membrane for chronic wound healing 2016 Herrmann, Isabel QC Physics In the present work an electrospun nanofibrous membrane composed of polyurethane (PU), sodium bicarbonate (NaHCO3) and pantothenic acid (PA) is developed for treating chronic wounds. Wounds are a common health problem and in particular, the chronic wounds such as vascular ulcers, diabetic ulcers and pressure ulcers cause a large number of morbidity and mortality. The main problems of the chronic wounds are prolonged inflammation phase and presence of acidic environment. These events deactivate the operation of growth factors and also the progression of natural healing mechanism. So, various types of advanced textile based dressings are developed to address the clinical complications associated with chronic wound management. The prepared electrospun scaffolds were characterised to study their physicochemical and hemocompatible properties. The SEM micrographs depicted continuous, smooth-interconnected nanofibrous morphology of PU-NaHCO3-PA scaffolds. The FTIR spectra indicated the addition of NaHCO3 and PA-based hydrophilic chemical groups which significantly enhanced the wettability of the composites. Further, the PU-NaHCO3 -PA composite membrane inferred to have a highly porous structure with the mean porosity of 79.4% ± 4.8% which may provide a conducive environment for adherence and proliferation of skin cells. The composite scaffold also offers a highly hemocompatible surface by delaying coagulation of blood through contact activation pathways and by limiting red blood cells damage. Therefore, the excellent physicochemical properties, blood compatibility and the delivery of PA are anticipated to speed up the impaired healing process of chronic wounds. 2016 Thesis http://eprints.utm.my/id/eprint/85868/ http://eprints.utm.my/id/eprint/85868/1/IsabelHerrmannMFBME2016.pdf application/pdf en public http://dms.library.utm.my:8080/vital/access/manager/Repository/vital:132553 masters Universiti Teknologi Malaysia, Faculty of Engineering - School of Biomedical Engineering & Health Sciences Faculty of Engineering - School of Biomedical Engineering & Health Sciences
institution	Universiti Teknologi Malaysia
collection	UTM Institutional Repository
language	English
topic	QC Physics
spellingShingle	QC Physics Herrmann, Isabel A novel electrospun nanofibrous composite membrane for chronic wound healing
description	In the present work an electrospun nanofibrous membrane composed of polyurethane (PU), sodium bicarbonate (NaHCO3) and pantothenic acid (PA) is developed for treating chronic wounds. Wounds are a common health problem and in particular, the chronic wounds such as vascular ulcers, diabetic ulcers and pressure ulcers cause a large number of morbidity and mortality. The main problems of the chronic wounds are prolonged inflammation phase and presence of acidic environment. These events deactivate the operation of growth factors and also the progression of natural healing mechanism. So, various types of advanced textile based dressings are developed to address the clinical complications associated with chronic wound management. The prepared electrospun scaffolds were characterised to study their physicochemical and hemocompatible properties. The SEM micrographs depicted continuous, smooth-interconnected nanofibrous morphology of PU-NaHCO3-PA scaffolds. The FTIR spectra indicated the addition of NaHCO3 and PA-based hydrophilic chemical groups which significantly enhanced the wettability of the composites. Further, the PU-NaHCO3 -PA composite membrane inferred to have a highly porous structure with the mean porosity of 79.4% ± 4.8% which may provide a conducive environment for adherence and proliferation of skin cells. The composite scaffold also offers a highly hemocompatible surface by delaying coagulation of blood through contact activation pathways and by limiting red blood cells damage. Therefore, the excellent physicochemical properties, blood compatibility and the delivery of PA are anticipated to speed up the impaired healing process of chronic wounds.
format	Thesis
qualification_level	Master's degree
author	Herrmann, Isabel
author_facet	Herrmann, Isabel
author_sort	Herrmann, Isabel
title	A novel electrospun nanofibrous composite membrane for chronic wound healing
title_short	A novel electrospun nanofibrous composite membrane for chronic wound healing
title_full	A novel electrospun nanofibrous composite membrane for chronic wound healing
title_fullStr	A novel electrospun nanofibrous composite membrane for chronic wound healing
title_full_unstemmed	A novel electrospun nanofibrous composite membrane for chronic wound healing
title_sort	novel electrospun nanofibrous composite membrane for chronic wound healing
granting_institution	Universiti Teknologi Malaysia, Faculty of Engineering - School of Biomedical Engineering & Health Sciences
granting_department	Faculty of Engineering - School of Biomedical Engineering & Health Sciences
publishDate	2016
url	http://eprints.utm.my/id/eprint/85868/1/IsabelHerrmannMFBME2016.pdf
_version_	1747818467709419520

A novel electrospun nanofibrous composite membrane for chronic wound healing

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