Floating kappa carrageenan based hydrogel with graphene oxide nanoparticles

Incorporation of nanoparticles in drug vehicle has attracted much attention in the area of drug delivery application due to its unique properties. It is hypothesised graphene oxide (GO) nanoparticles incorporation can provide excellent hydrogel properties with effective drug vehicle. In this work, G...

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Main Author:	Mohamad Sis, Mohamad Azim
Format:	Thesis
Language:	English
Published:	2017
Subjects:	TP Chemical technology
Online Access:	http://eprints.utm.my/id/eprint/86035/1/MuhamadAzimMohamadSisMSChE2017.pdf
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spelling	my-utm-ep.860352020-08-30T08:49:42Z Floating kappa carrageenan based hydrogel with graphene oxide nanoparticles 2017 Mohamad Sis, Mohamad Azim TP Chemical technology Incorporation of nanoparticles in drug vehicle has attracted much attention in the area of drug delivery application due to its unique properties. It is hypothesised graphene oxide (GO) nanoparticles incorporation can provide excellent hydrogel properties with effective drug vehicle. In this work, GO nanoparticles are used in the formulation of floating hydrogel prepared using ?-carrageenan, sodium carboxymethyl cellulose and calcium carbonates. Calcium carbonate is added as effervescent agents to promote the buoyancy effect. Floating hydrogel without GO nanoparticle and floating hydrogel with GO nanoparticle act as controls. The analyses were carried out on swelling degree, antibacterial study, floating properties and in vitro methylene blue released as modelled drug. The properties of drug carrier were analysed using Fourier transform infrared spectroscopy (FTIR), TGA and Variable Pressure Scanning Electron Microscope (VPSEM). GO-loaded floating nanocomposite hydrogels showed significant effect on swelling ratio which is reduced more than 50% but did not much effect on kinetic reaction with acidic pH1.2 buffer solution. Antibacterial properties were proved based on positive result that inhibited spore growth within 96hours. In vitro released profile with additional 0.01% GO was slower (5.4%) compared to the controls. In summary, GO nanoparticles-loaded ?-carrageenan based floating nanocomposite hydrogel has a significant floating potential that could be used as prospective drug carrier in gastrointestinal tract. 2017 Thesis http://eprints.utm.my/id/eprint/86035/ http://eprints.utm.my/id/eprint/86035/1/MuhamadAzimMohamadSisMSChE2017.pdf application/pdf en public http://dms.library.utm.my:8080/vital/access/manager/Repository/vital:131611 masters Universiti Teknologi Malaysia, Faculty of Engineering - School of Chemical & Energy Engineering Faculty of Engineering - School of Chemical & Energy Engineering
institution	Universiti Teknologi Malaysia
collection	UTM Institutional Repository
language	English
topic	TP Chemical technology
spellingShingle	TP Chemical technology Mohamad Sis, Mohamad Azim Floating kappa carrageenan based hydrogel with graphene oxide nanoparticles
description	Incorporation of nanoparticles in drug vehicle has attracted much attention in the area of drug delivery application due to its unique properties. It is hypothesised graphene oxide (GO) nanoparticles incorporation can provide excellent hydrogel properties with effective drug vehicle. In this work, GO nanoparticles are used in the formulation of floating hydrogel prepared using ?-carrageenan, sodium carboxymethyl cellulose and calcium carbonates. Calcium carbonate is added as effervescent agents to promote the buoyancy effect. Floating hydrogel without GO nanoparticle and floating hydrogel with GO nanoparticle act as controls. The analyses were carried out on swelling degree, antibacterial study, floating properties and in vitro methylene blue released as modelled drug. The properties of drug carrier were analysed using Fourier transform infrared spectroscopy (FTIR), TGA and Variable Pressure Scanning Electron Microscope (VPSEM). GO-loaded floating nanocomposite hydrogels showed significant effect on swelling ratio which is reduced more than 50% but did not much effect on kinetic reaction with acidic pH1.2 buffer solution. Antibacterial properties were proved based on positive result that inhibited spore growth within 96hours. In vitro released profile with additional 0.01% GO was slower (5.4%) compared to the controls. In summary, GO nanoparticles-loaded ?-carrageenan based floating nanocomposite hydrogel has a significant floating potential that could be used as prospective drug carrier in gastrointestinal tract.
format	Thesis
qualification_level	Master's degree
author	Mohamad Sis, Mohamad Azim
author_facet	Mohamad Sis, Mohamad Azim
author_sort	Mohamad Sis, Mohamad Azim
title	Floating kappa carrageenan based hydrogel with graphene oxide nanoparticles
title_short	Floating kappa carrageenan based hydrogel with graphene oxide nanoparticles
title_full	Floating kappa carrageenan based hydrogel with graphene oxide nanoparticles
title_fullStr	Floating kappa carrageenan based hydrogel with graphene oxide nanoparticles
title_full_unstemmed	Floating kappa carrageenan based hydrogel with graphene oxide nanoparticles
title_sort	floating kappa carrageenan based hydrogel with graphene oxide nanoparticles
granting_institution	Universiti Teknologi Malaysia, Faculty of Engineering - School of Chemical & Energy Engineering
granting_department	Faculty of Engineering - School of Chemical & Energy Engineering
publishDate	2017
url	http://eprints.utm.my/id/eprint/86035/1/MuhamadAzimMohamadSisMSChE2017.pdf
_version_	1747818483958153216

Floating kappa carrageenan based hydrogel with graphene oxide nanoparticles

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