Particle depositions in multi stage liquid impinger as simplified lung model using computational fluid dynamic

Inhaled medication is typically used to treat obstructive pulmonary disease and systemic diseases. The effectiveness of pulmonary drug delivery depends on the amount of drug deposited beyond the oropharyngeal region, the place where the deposition and the uniform distribution occurred. In this study...

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Main Author:	Azmi, Musfirah
Format:	Thesis
Language:	English
Published:	2019
Subjects:	TP Chemical technology
Online Access:	http://eprints.utm.my/id/eprint/86068/1/MusfirahAzmiMSChE2019.pdf
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spelling	my-utm-ep.860682020-08-30T08:53:19Z Particle depositions in multi stage liquid impinger as simplified lung model using computational fluid dynamic 2019 Azmi, Musfirah TP Chemical technology Inhaled medication is typically used to treat obstructive pulmonary disease and systemic diseases. The effectiveness of pulmonary drug delivery depends on the amount of drug deposited beyond the oropharyngeal region, the place where the deposition and the uniform distribution occurred. In this study, the performance of multistage liquid impinger (MSLI) simplified model which imitates the physiological lung in delivering the drug was analyzed. In order to achieve this main aim, the airflow patterns and particle depositions efficiency were evaluated in MSLI simplified model using computational fluid dynamic of COMSOL® software. The particle deposition efficiency is studied by varying flowrates (30.0 L/min, 60.0 L/min and 100.0 L/min) and particle sizes (0.1, 1.0, 3.0, 5.0, 10.0 pm) of salbutamol sulphate (density 20.0 kg/m3). The highest particle deposition occurred at flowrate 100.0 L/min and particle size of 1.0 pm as the deposition yield was 15.55% compared to flowrate 60 L/min and 30 L/min which were 10.50% and 3.09% respectively. Previous studies claimed that higher inhalation flowrate generated dispersion forces for sufficient inhalation flowrate thus enhanced higher deposition efficiency. The paired-samples T-test shows there were significant different (t= -15.400, df= 4, p <0.05) in the performance of particle depositions in MSLI simplified model with different flow rates (60.0 L/min and 100.0 L/min). Thus, the efficient fine particle deposition was significantly contributed by higher flowrate. This study also revealed that particle size ranges from 1.0 to 3.0 pm was the most suitable for inhalation treatment. Smaller particle size less than 1.0 pm was not suitable as it tended to exhale before it deposit of while larger particle (more than 5.0 pm) was not suitable for inhaled drug. In conclusion, vigorous air flow pattern promotes higher particle deposition. For efficient fine particle depositions, it is important to consider not only the particle size distribution, but also the flowrate as vital aerosol transportation agent. Statistical analysis, two-way ANOVA indicated that there was a statistically significant interaction between the effect of flowrate and particle size on particle deposition efficiency, F (8, 30)=5.857, p=0.00. 2019 Thesis http://eprints.utm.my/id/eprint/86068/ http://eprints.utm.my/id/eprint/86068/1/MusfirahAzmiMSChE2019.pdf application/pdf en public http://dms.library.utm.my:8080/vital/access/manager/Repository/vital:131577 masters Universiti Teknologi Malaysia, Faculty of Engineering - School of Chemical & Energy Engineering Faculty of Engineering - School of Chemical & Energy Engineering
institution	Universiti Teknologi Malaysia
collection	UTM Institutional Repository
language	English
topic	TP Chemical technology
spellingShingle	TP Chemical technology Azmi, Musfirah Particle depositions in multi stage liquid impinger as simplified lung model using computational fluid dynamic
description	Inhaled medication is typically used to treat obstructive pulmonary disease and systemic diseases. The effectiveness of pulmonary drug delivery depends on the amount of drug deposited beyond the oropharyngeal region, the place where the deposition and the uniform distribution occurred. In this study, the performance of multistage liquid impinger (MSLI) simplified model which imitates the physiological lung in delivering the drug was analyzed. In order to achieve this main aim, the airflow patterns and particle depositions efficiency were evaluated in MSLI simplified model using computational fluid dynamic of COMSOL® software. The particle deposition efficiency is studied by varying flowrates (30.0 L/min, 60.0 L/min and 100.0 L/min) and particle sizes (0.1, 1.0, 3.0, 5.0, 10.0 pm) of salbutamol sulphate (density 20.0 kg/m3). The highest particle deposition occurred at flowrate 100.0 L/min and particle size of 1.0 pm as the deposition yield was 15.55% compared to flowrate 60 L/min and 30 L/min which were 10.50% and 3.09% respectively. Previous studies claimed that higher inhalation flowrate generated dispersion forces for sufficient inhalation flowrate thus enhanced higher deposition efficiency. The paired-samples T-test shows there were significant different (t= -15.400, df= 4, p <0.05) in the performance of particle depositions in MSLI simplified model with different flow rates (60.0 L/min and 100.0 L/min). Thus, the efficient fine particle deposition was significantly contributed by higher flowrate. This study also revealed that particle size ranges from 1.0 to 3.0 pm was the most suitable for inhalation treatment. Smaller particle size less than 1.0 pm was not suitable as it tended to exhale before it deposit of while larger particle (more than 5.0 pm) was not suitable for inhaled drug. In conclusion, vigorous air flow pattern promotes higher particle deposition. For efficient fine particle depositions, it is important to consider not only the particle size distribution, but also the flowrate as vital aerosol transportation agent. Statistical analysis, two-way ANOVA indicated that there was a statistically significant interaction between the effect of flowrate and particle size on particle deposition efficiency, F (8, 30)=5.857, p=0.00.
format	Thesis
qualification_level	Master's degree
author	Azmi, Musfirah
author_facet	Azmi, Musfirah
author_sort	Azmi, Musfirah
title	Particle depositions in multi stage liquid impinger as simplified lung model using computational fluid dynamic
title_short	Particle depositions in multi stage liquid impinger as simplified lung model using computational fluid dynamic
title_full	Particle depositions in multi stage liquid impinger as simplified lung model using computational fluid dynamic
title_fullStr	Particle depositions in multi stage liquid impinger as simplified lung model using computational fluid dynamic
title_full_unstemmed	Particle depositions in multi stage liquid impinger as simplified lung model using computational fluid dynamic
title_sort	particle depositions in multi stage liquid impinger as simplified lung model using computational fluid dynamic
granting_institution	Universiti Teknologi Malaysia, Faculty of Engineering - School of Chemical & Energy Engineering
granting_department	Faculty of Engineering - School of Chemical & Energy Engineering
publishDate	2019
url	http://eprints.utm.my/id/eprint/86068/1/MusfirahAzmiMSChE2019.pdf
_version_	1747818490325106688

Particle depositions in multi stage liquid impinger as simplified lung model using computational fluid dynamic

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