Extraction and optimization of phytochemicals from Curcuma xanthorrhiza Roxb.

Curcuma xanthorrhiza belongs to the Zingiberaceae family is a rich source of phenolics and terpenoids with various bioactivities. The essential oil from the rhizomes was obtained by hydro-distillation and analyzed by gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS). Xanthorrh...

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Main Author:	Azemi, Najiba
Format:	Thesis
Language:	English
Published:	2020
Subjects:	QD Chemistry
Online Access:	http://eprints.utm.my/id/eprint/99529/1/NajebaAzemiMFS2020.pdf.pdf
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spelling	my-utm-ep.995292023-03-01T07:32:51Z Extraction and optimization of phytochemicals from Curcuma xanthorrhiza Roxb. 2020 Azemi, Najiba QD Chemistry Curcuma xanthorrhiza belongs to the Zingiberaceae family is a rich source of phenolics and terpenoids with various bioactivities. The essential oil from the rhizomes was obtained by hydro-distillation and analyzed by gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS). Xanthorrhizol (1), ar-curcumene (4), and a-cedrene (18) were found as the most abundant constituents in the essential oil. Optimization of the ultrasound-assisted extraction (UAE) of the extract from the rhizomes of C. xanthorrhiza was carried out via response surface methodology (RSM). Seventeen experiments were developed with Box-Behnken design (BBD) using three variables which are extraction time (5, 12.50, 20 min), temperature (30, 40, 50°C), and liquid-solid ratio (6, 8, 10 mL/g), respectively. The effect of parameters on the responses of extraction yield, quantification of xanthorrhizol (1), and curcumin (2) was determined. In the extracts, xanthorrhizol (1) and curcumin (2) were quantified using reversed-phase high-performance liquid chromatography (RP HPLC) combined with a photodiode array detector. The highest percentage of yield (72.20%) and the concentration of xanthorrhizol (1) (85.68% w/w) were found at the extraction temperature of 50°C, time of 20 minutes and 8 mL/g liquid-solid ratio. The highest concentration of curcumin (2) (39.73% w/w) was found at the extraction temperature of 30°C, time of 12.50 minutes, and 10 mL/g liquid-solid ratio. Experimental values are closely agreed with the predicted values. The determination coefficient (R2) of extraction yield, xanthorrhizol (1), and curcumin (2) are 0.9960, 0.9983, and 0.9990, respectively. The variance analysis (ANOVA) showed good quadratic model. The numerical data suggested the success of the RSM method in optimizing the phytochemicals extraction parameters from the rhizomes of C. xanthorrhiza. 2020 Thesis http://eprints.utm.my/id/eprint/99529/ http://eprints.utm.my/id/eprint/99529/1/NajebaAzemiMFS2020.pdf.pdf application/pdf en public http://dms.library.utm.my:8080/vital/access/manager/Repository/vital:146099 masters Universiti Teknologi Malaysia Faculty of Engineering - School of Chemical & Energy Engineering
institution	Universiti Teknologi Malaysia
collection	UTM Institutional Repository
language	English
topic	QD Chemistry
spellingShingle	QD Chemistry Azemi, Najiba Extraction and optimization of phytochemicals from Curcuma xanthorrhiza Roxb.
description	Curcuma xanthorrhiza belongs to the Zingiberaceae family is a rich source of phenolics and terpenoids with various bioactivities. The essential oil from the rhizomes was obtained by hydro-distillation and analyzed by gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS). Xanthorrhizol (1), ar-curcumene (4), and a-cedrene (18) were found as the most abundant constituents in the essential oil. Optimization of the ultrasound-assisted extraction (UAE) of the extract from the rhizomes of C. xanthorrhiza was carried out via response surface methodology (RSM). Seventeen experiments were developed with Box-Behnken design (BBD) using three variables which are extraction time (5, 12.50, 20 min), temperature (30, 40, 50°C), and liquid-solid ratio (6, 8, 10 mL/g), respectively. The effect of parameters on the responses of extraction yield, quantification of xanthorrhizol (1), and curcumin (2) was determined. In the extracts, xanthorrhizol (1) and curcumin (2) were quantified using reversed-phase high-performance liquid chromatography (RP HPLC) combined with a photodiode array detector. The highest percentage of yield (72.20%) and the concentration of xanthorrhizol (1) (85.68% w/w) were found at the extraction temperature of 50°C, time of 20 minutes and 8 mL/g liquid-solid ratio. The highest concentration of curcumin (2) (39.73% w/w) was found at the extraction temperature of 30°C, time of 12.50 minutes, and 10 mL/g liquid-solid ratio. Experimental values are closely agreed with the predicted values. The determination coefficient (R2) of extraction yield, xanthorrhizol (1), and curcumin (2) are 0.9960, 0.9983, and 0.9990, respectively. The variance analysis (ANOVA) showed good quadratic model. The numerical data suggested the success of the RSM method in optimizing the phytochemicals extraction parameters from the rhizomes of C. xanthorrhiza.
format	Thesis
qualification_level	Master's degree
author	Azemi, Najiba
author_facet	Azemi, Najiba
author_sort	Azemi, Najiba
title	Extraction and optimization of phytochemicals from Curcuma xanthorrhiza Roxb.
title_short	Extraction and optimization of phytochemicals from Curcuma xanthorrhiza Roxb.
title_full	Extraction and optimization of phytochemicals from Curcuma xanthorrhiza Roxb.
title_fullStr	Extraction and optimization of phytochemicals from Curcuma xanthorrhiza Roxb.
title_full_unstemmed	Extraction and optimization of phytochemicals from Curcuma xanthorrhiza Roxb.
title_sort	extraction and optimization of phytochemicals from curcuma xanthorrhiza roxb.
granting_institution	Universiti Teknologi Malaysia
granting_department	Faculty of Engineering - School of Chemical & Energy Engineering
publishDate	2020
url	http://eprints.utm.my/id/eprint/99529/1/NajebaAzemiMFS2020.pdf.pdf
_version_	1776100612489871360

Extraction and optimization of phytochemicals from Curcuma xanthorrhiza Roxb.

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