Prevalance and risk factors of Entamoeba species infections among Orang Asli school children in Perak
<p>This study aims to investigate the molecular epidemiology and risk factors of</p><p>Entamoeba histolytica, Entamoeba dispar, and Entamoeba moshkovskii infection</p><p>among Orang Asli school children in Perak. Stool samples wer...
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| Format: | thesis |
| Language: | eng |
| Published: |
2023
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| Subjects: | |
| Online Access: | https://ir.upsi.edu.my/detailsg.php?det=10097 |
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| Summary: | <p>This study aims to investigate the molecular epidemiology and risk factors of</p><p>Entamoeba histolytica, Entamoeba dispar, and Entamoeba moshkovskii infection</p><p>among Orang Asli school children in Perak. Stool samples were collected from 544</p><p>school children and the DNA extracted were amplified using nested multiplex PCR.</p><p>The univariate and multivariate regression analyses were then used to determine the</p><p>risk factor associated with Entamoeba species infection. The overall prevalence of</p><p>Entamoeba complex infections was 21.3% (116/544). The total of school children</p><p>infected with E. moshkovskii was 10.7% (58/544) followed by 9.0% (49/544) of E.</p><p>dispar and 5.0% (27/544) of E. histolytica. One sample was positive for the mixed E.</p><p>histolytica and E. dispar infection, five samples were positive for the mixed E.</p><p>histolytica and E. moshkovskii infection, and 12 samples were positive for the mixed</p><p>E. dispar and E. moshkovskii infection. As a result of the univariate analysis, there</p><p>were 19 statistically significant factors, but only one remained a significant risk factor</p><p>for E. histolytica infection in the logistic regression model, namely not washing hands</p><p>after using the toilet. Meanwhile, risk factors for E. moshkovskii infection were school</p><p>children older than 10 years old, possessed high BMI, stayed with working mother,</p><p>have uneducated mothers, absence of toilet in the house, not washing hands after</p><p>using the toilet, and having clinical symptoms of fever. On the other hand, drinking</p><p>water from the river, well, and rain was associated with a decreased risk of E. dispar</p><p>infection. In conclusion, these findings showed a high prevalence of Entamoeba</p><p>species infection among Orang Asli school children in Perak. Thus, the implication of</p><p>this study shows that elucidation of species-specific risk factors will be the key in</p><p>reducing protozoan parasite transmission among Orang Asli children.</p> |
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