Extraction and isolation of alkaloids from the leaves of alseodaphne corneri (Lauraceae) (IR)

This phytochemical study is aimed to extract, isolate and identify alkaloids from Alseodaphne corneri leaves. The crude alkaloid was extracted by cold percolation followed by acid-base extraction until Mayer test showed negative result. Then, it was separated by conventional chromatographic methods...

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Main Author:	Jennie, Khoo Hui Chen
Format:	thesis
Language:	eng
Published:	2015
Subjects:	QD Chemistry
Online Access:	https://ir.upsi.edu.my/detailsg.php?det=1639
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spelling	oai:ir.upsi.edu.my:16392020-02-27 Extraction and isolation of alkaloids from the leaves of alseodaphne corneri (Lauraceae) (IR) 2015 Jennie, Khoo Hui Chen QD Chemistry This phytochemical study is aimed to extract, isolate and identify alkaloids from Alseodaphne corneri leaves. The crude alkaloid was extracted by cold percolation followed by acid-base extraction until Mayer test showed negative result. Then, it was separated by conventional chromatographic methods using column chromatography and preparative thin layer chromatography. The structural elucidation of isolated alkaloids was then carried out by spectroscopic techniques; UV, IR, NMR and HRESIMS. The structures of the compounds were also determined by comparison with previous study. Isolation of alkaloids yielded one new benzylisoquinoline; (6,7- dimethoxyisoquinolinyl)-(2',5'-dihydroxy-4'-methoxyphenyl)-methanone 68, one bisbenylisoquinoline; obamegine 49, one oxoaporphines; atheroline 71, and five aporphine; isocorydine 48, N-methyllaurotetanine 51, laurotetanine 53, lirioferine 69 and norlirioferine 70. The benzylisoquinoline type alkaloid, lirioferine 69 and atheroline 71 were first reported in Alseodaphne genus while norlirioferine 70 was first isolated from Alseodaphne corneri species. These findings are very important as the elucidated alkaloids can be referred in future especially in identification of new alkaloid compound. 2015 thesis https://ir.upsi.edu.my/detailsg.php?det=1639 https://ir.upsi.edu.my/detailsg.php?det=1639 text eng closedAccess Masters Universiti Pendidikan Sultan Idris Fakulti Sains dan Matematik N/A
institution	Universiti Pendidikan Sultan Idris
collection	UPSI Digital Repository
language	eng
topic	QD Chemistry
spellingShingle	QD Chemistry Jennie, Khoo Hui Chen Extraction and isolation of alkaloids from the leaves of alseodaphne corneri (Lauraceae) (IR)
description	This phytochemical study is aimed to extract, isolate and identify alkaloids from Alseodaphne corneri leaves. The crude alkaloid was extracted by cold percolation followed by acid-base extraction until Mayer test showed negative result. Then, it was separated by conventional chromatographic methods using column chromatography and preparative thin layer chromatography. The structural elucidation of isolated alkaloids was then carried out by spectroscopic techniques; UV, IR, NMR and HRESIMS. The structures of the compounds were also determined by comparison with previous study. Isolation of alkaloids yielded one new benzylisoquinoline; (6,7- dimethoxyisoquinolinyl)-(2',5'-dihydroxy-4'-methoxyphenyl)-methanone 68, one bisbenylisoquinoline; obamegine 49, one oxoaporphines; atheroline 71, and five aporphine; isocorydine 48, N-methyllaurotetanine 51, laurotetanine 53, lirioferine 69 and norlirioferine 70. The benzylisoquinoline type alkaloid, lirioferine 69 and atheroline 71 were first reported in Alseodaphne genus while norlirioferine 70 was first isolated from Alseodaphne corneri species. These findings are very important as the elucidated alkaloids can be referred in future especially in identification of new alkaloid compound.
format	thesis
qualification_name
qualification_level	Master's degree
author	Jennie, Khoo Hui Chen
author_facet	Jennie, Khoo Hui Chen
author_sort	Jennie, Khoo Hui Chen
title	Extraction and isolation of alkaloids from the leaves of alseodaphne corneri (Lauraceae) (IR)
title_short	Extraction and isolation of alkaloids from the leaves of alseodaphne corneri (Lauraceae) (IR)
title_full	Extraction and isolation of alkaloids from the leaves of alseodaphne corneri (Lauraceae) (IR)
title_fullStr	Extraction and isolation of alkaloids from the leaves of alseodaphne corneri (Lauraceae) (IR)
title_full_unstemmed	Extraction and isolation of alkaloids from the leaves of alseodaphne corneri (Lauraceae) (IR)
title_sort	extraction and isolation of alkaloids from the leaves of alseodaphne corneri (lauraceae) (ir)
granting_institution	Universiti Pendidikan Sultan Idris
granting_department	Fakulti Sains dan Matematik
publishDate	2015
url	https://ir.upsi.edu.my/detailsg.php?det=1639
_version_	1747832985590169600

Extraction and isolation of alkaloids from the leaves of alseodaphne corneri (Lauraceae) (IR)

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