Chemical constituents from Ficus deltoidea var. kunstleri corner and its antidiabetic property (IR)
<p>The aims of this study are to determine the chemical structures of the isolated compounds from the leaves and stem bark of Ficus deltoidea var. kunstleri by using various type of spectroscopy and to evaluate their antidiabetic activities. The isolation process of isolated compounds...
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| Format: | thesis |
| Language: | eng |
| Published: |
2017
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| Subjects: | |
| Online Access: | https://ir.upsi.edu.my/detailsg.php?det=3349 |
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| Summary: | <p>The aims of this study are to determine the chemical structures of the isolated compounds from the leaves and stem bark of Ficus deltoidea var. kunstleri by using various type of spectroscopy and to evaluate their antidiabetic activities. The isolation process of isolated compounds involved extraction, separation and purification by using column chromatography and preparative thin layer chromatography techniques. These compounds were structurally identified by using various spectroscopic techniques such as 1D (1H,13C and DEPT) and 2D-NMR (HMBC,HMQC and COSY), UV, IR and mass spectrometry; and also by comparison with previous studies. Study on in-vitro antidiabetic activities were evaluated by using -glucosidase inhibitory assay with 4- nitrophenyl--D-glucopyranoside (pNPG) as substrate. As findings, chromatographic purification of F. deltoidea var. kunstleri afforded eleven chemical compounds: - tocopherol, -amyrin cinnamate, triglycerides fatty acids, hexadecyl palmitate, bergapten which are first time reported from this species and two mixture of compounds; mixture of pentacyclic triterpenes; lupeol, -amyrin, -amyrin and a mixture of sterols; stigmasterol and -sitosterol together with a new ester triterpene; euphol ester. The bioactivity of glucosidase inhibition on the crude extracts and isolated compounds from this variation was first time reported. As conclusion, all crude extracts and the isolated compounds were inactive against the in-vitro -glucosidase activity and have no potential as antidiabetic drugs. The implication is the results from this study can be used as future references to discover possible potential new drugs.</p> |
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