Chemical constituents from Ficus deltoidea var. kunstleri corner and its antidiabetic property (IR)

<p>The aims of this study are to determine the chemical structures of the isolated compounds from the leaves and stem bark of Ficus deltoidea var. kunstleri by using various type of spectroscopy and to evaluate their antidiabetic activities. The isolation process of isolated compounds...

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Main Author:	Nor Afifah Md Jamal
Format:	thesis
Language:	eng
Published:	2017
Subjects:	QK Botany
Online Access:	https://ir.upsi.edu.my/detailsg.php?det=3349
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spelling	oai:ir.upsi.edu.my:33492020-02-27 Chemical constituents from Ficus deltoidea var. kunstleri corner and its antidiabetic property (IR) 2017 Nor Afifah Md Jamal QK Botany <p>The aims of this study are to determine the chemical structures of the isolated compounds from the leaves and stem bark of Ficus deltoidea var. kunstleri by using various type of spectroscopy and to evaluate their antidiabetic activities. The isolation process of isolated compounds involved extraction, separation and purification by using column chromatography and preparative thin layer chromatography techniques. These compounds were structurally identified by using various spectroscopic techniques such as 1D (1H,13C and DEPT) and 2D-NMR (HMBC,HMQC and COSY), UV, IR and mass spectrometry; and also by comparison with previous studies. Study on in-vitro antidiabetic activities were evaluated by using -glucosidase inhibitory assay with 4- nitrophenyl--D-glucopyranoside (pNPG) as substrate. As findings, chromatographic purification of F. deltoidea var. kunstleri afforded eleven chemical compounds: - tocopherol, -amyrin cinnamate, triglycerides fatty acids, hexadecyl palmitate, bergapten which are first time reported from this species and two mixture of compounds; mixture of pentacyclic triterpenes; lupeol, -amyrin, -amyrin and a mixture of sterols; stigmasterol and -sitosterol together with a new ester triterpene; euphol ester. The bioactivity of glucosidase inhibition on the crude extracts and isolated compounds from this variation was first time reported. As conclusion, all crude extracts and the isolated compounds were inactive against the in-vitro -glucosidase activity and have no potential as antidiabetic drugs. The implication is the results from this study can be used as future references to discover possible potential new drugs.</p> 2017 thesis https://ir.upsi.edu.my/detailsg.php?det=3349 https://ir.upsi.edu.my/detailsg.php?det=3349 text eng closedAccess Masters Universiti Pendidikan Sultan Idris Fakulti Sains dan Matematik N/A
institution	Universiti Pendidikan Sultan Idris
collection	UPSI Digital Repository
language	eng
topic	QK Botany
spellingShingle	QK Botany Nor Afifah Md Jamal Chemical constituents from Ficus deltoidea var. kunstleri corner and its antidiabetic property (IR)
description	<p>The aims of this study are to determine the chemical structures of the isolated compounds from the leaves and stem bark of Ficus deltoidea var. kunstleri by using various type of spectroscopy and to evaluate their antidiabetic activities. The isolation process of isolated compounds involved extraction, separation and purification by using column chromatography and preparative thin layer chromatography techniques. These compounds were structurally identified by using various spectroscopic techniques such as 1D (1H,13C and DEPT) and 2D-NMR (HMBC,HMQC and COSY), UV, IR and mass spectrometry; and also by comparison with previous studies. Study on in-vitro antidiabetic activities were evaluated by using -glucosidase inhibitory assay with 4- nitrophenyl--D-glucopyranoside (pNPG) as substrate. As findings, chromatographic purification of F. deltoidea var. kunstleri afforded eleven chemical compounds: - tocopherol, -amyrin cinnamate, triglycerides fatty acids, hexadecyl palmitate, bergapten which are first time reported from this species and two mixture of compounds; mixture of pentacyclic triterpenes; lupeol, -amyrin, -amyrin and a mixture of sterols; stigmasterol and -sitosterol together with a new ester triterpene; euphol ester. The bioactivity of glucosidase inhibition on the crude extracts and isolated compounds from this variation was first time reported. As conclusion, all crude extracts and the isolated compounds were inactive against the in-vitro -glucosidase activity and have no potential as antidiabetic drugs. The implication is the results from this study can be used as future references to discover possible potential new drugs.</p>
format	thesis
qualification_name
qualification_level	Master's degree
author	Nor Afifah Md Jamal
author_facet	Nor Afifah Md Jamal
author_sort	Nor Afifah Md Jamal
title	Chemical constituents from Ficus deltoidea var. kunstleri corner and its antidiabetic property (IR)
title_short	Chemical constituents from Ficus deltoidea var. kunstleri corner and its antidiabetic property (IR)
title_full	Chemical constituents from Ficus deltoidea var. kunstleri corner and its antidiabetic property (IR)
title_fullStr	Chemical constituents from Ficus deltoidea var. kunstleri corner and its antidiabetic property (IR)
title_full_unstemmed	Chemical constituents from Ficus deltoidea var. kunstleri corner and its antidiabetic property (IR)
title_sort	chemical constituents from ficus deltoidea var. kunstleri corner and its antidiabetic property (ir)
granting_institution	Universiti Pendidikan Sultan Idris
granting_department	Fakulti Sains dan Matematik
publishDate	2017
url	https://ir.upsi.edu.my/detailsg.php?det=3349
_version_	1747833073157799936

Chemical constituents from Ficus deltoidea var. kunstleri corner and its antidiabetic property (IR)

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