Study on alkaloids from the roots of Murraya koenigii (IR)

<p>The aims of this study were to determine the phytochemical constituents from the roots of Murraya koenigii and to test the antidiabetic activities. The isolation and purification of the chemical compounds involves extraction and separations by using various chromatographic methods a...

Full description

Saved in:

Bibliographic Details
Main Author:	Adilah Shahidan
Format:	thesis
Language:	eng
Published:	2017
Subjects:	QK Botany
Online Access:	https://ir.upsi.edu.my/detailsg.php?det=3385
Tags:	Add Tag No Tags, Be the first to tag this record!

id	oai:ir.upsi.edu.my:3385
record_format	uketd_dc
spelling	oai:ir.upsi.edu.my:33852020-02-27 Study on alkaloids from the roots of Murraya koenigii (IR) 2017 Adilah Shahidan QK Botany <p>The aims of this study were to determine the phytochemical constituents from the roots of Murraya koenigii and to test the antidiabetic activities. The isolation and purification of the chemical compounds involves extraction and separations by using various chromatographic methods and structural determination by specttroscopic techniques such as ultraviolet (UV), infrared (IR), mass spectroscopy (MS) and nuclear magnetic resonance (NMR) including 1D-NMR (1H, 13C and DEPT) and 2DNMR (COSY, HMQC and HMBC). The structure of the isolated compounds were compared with previous work done by other researcher. Isolation studies on the roots of Malayan M. koenigii collected from Jerantut, Pahang involving hexane, dichloromethane and methanol extract yielded eight compounds. Hexane crude extracts gave two compounds; girinimbine and murrayafoline A, while five compounds were successfully isolated from the dichloromethane crude extracts known as mahanimbine, murrayanine, 3-formylcarbazole, N-methoxy-3- hydroxymethyl-9H-carbazole and koenoline. Futher investigation on the methanol crude extracts afforded one new indole alkaloid named 2-hydroxy-3,5- dimethoxyindole. In a parallel investigation, the antidiabetic activity were also tested on all crude extracts and isolated compounds. It showed negative results on antidiabetic activity test. The implication of the data obtained from this study can be use as a reference for other researchers to conduct studies on M. koenigii. In conclusion, the study successfully isolated and purified eight compounds from roots of M. koenigii and tested for their antidiabetic activity.</p> 2017 thesis https://ir.upsi.edu.my/detailsg.php?det=3385 https://ir.upsi.edu.my/detailsg.php?det=3385 text eng closedAccess Masters Universiti Pendidikan Sultan Idris Fakulti Sains dan Matematik N/A
institution	Universiti Pendidikan Sultan Idris
collection	UPSI Digital Repository
language	eng
topic	QK Botany
spellingShingle	QK Botany Adilah Shahidan Study on alkaloids from the roots of Murraya koenigii (IR)
description	<p>The aims of this study were to determine the phytochemical constituents from the roots of Murraya koenigii and to test the antidiabetic activities. The isolation and purification of the chemical compounds involves extraction and separations by using various chromatographic methods and structural determination by specttroscopic techniques such as ultraviolet (UV), infrared (IR), mass spectroscopy (MS) and nuclear magnetic resonance (NMR) including 1D-NMR (1H, 13C and DEPT) and 2DNMR (COSY, HMQC and HMBC). The structure of the isolated compounds were compared with previous work done by other researcher. Isolation studies on the roots of Malayan M. koenigii collected from Jerantut, Pahang involving hexane, dichloromethane and methanol extract yielded eight compounds. Hexane crude extracts gave two compounds; girinimbine and murrayafoline A, while five compounds were successfully isolated from the dichloromethane crude extracts known as mahanimbine, murrayanine, 3-formylcarbazole, N-methoxy-3- hydroxymethyl-9H-carbazole and koenoline. Futher investigation on the methanol crude extracts afforded one new indole alkaloid named 2-hydroxy-3,5- dimethoxyindole. In a parallel investigation, the antidiabetic activity were also tested on all crude extracts and isolated compounds. It showed negative results on antidiabetic activity test. The implication of the data obtained from this study can be use as a reference for other researchers to conduct studies on M. koenigii. In conclusion, the study successfully isolated and purified eight compounds from roots of M. koenigii and tested for their antidiabetic activity.</p>
format	thesis
qualification_name
qualification_level	Master's degree
author	Adilah Shahidan
author_facet	Adilah Shahidan
author_sort	Adilah Shahidan
title	Study on alkaloids from the roots of Murraya koenigii (IR)
title_short	Study on alkaloids from the roots of Murraya koenigii (IR)
title_full	Study on alkaloids from the roots of Murraya koenigii (IR)
title_fullStr	Study on alkaloids from the roots of Murraya koenigii (IR)
title_full_unstemmed	Study on alkaloids from the roots of Murraya koenigii (IR)
title_sort	study on alkaloids from the roots of murraya koenigii (ir)
granting_institution	Universiti Pendidikan Sultan Idris
granting_department	Fakulti Sains dan Matematik
publishDate	2017
url	https://ir.upsi.edu.my/detailsg.php?det=3385
_version_	1747833078102884352

Study on alkaloids from the roots of Murraya koenigii (IR)

Similar Items