Voltammetric sensors for pharmaceutical using zinc layered hydroxide/multiwalled carbon nanotubes paste (IR)
This study aims to develop a voltammetric sensors of acetaminophen, dopamine and hydroquinone using zinc layered hydroxide-L-phenylalanate/multiwalled carbon nanotubes, zinc layered hydroxide-sodium dodecyl sulphate-isoprocarb/multiwalled carbon nanotubes and zinc layered hydroxide-ferulate/multiwal...
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| Main Author: | |
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| Format: | thesis |
| Language: | eng |
| Published: |
2018
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| Subjects: | |
| Online Access: | https://ir.upsi.edu.my/detailsg.php?det=4780 |
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| Summary: | This study aims to develop a voltammetric sensors of acetaminophen, dopamine and hydroquinone using zinc layered hydroxide-L-phenylalanate/multiwalled carbon nanotubes, zinc layered hydroxide-sodium dodecyl sulphate-isoprocarb/multiwalled carbon nanotubes and zinc layered hydroxide-ferulate/multiwalled carbon nanotubes, respectively. The surface morphology of these layered materials and multiwalled carbon nanotubes were determined using scanning electron microscope and transmission electron microscope, while the rate of electron transfer on the surface of these electrodes were determined by electrochemical impedance spectroscopy. The square wave voltammetry method was used to study the performance of these electrodes. Several experimental conditions influencing the voltammetric responses such as percentage of modifiers, type and concentration of supporting electrolyte, pH of the solutions and square wave voltammetry parameters were optimized. Under optimum conditions, these electrodes showed linear response ranges for the determination of acetaminophen, dopamine and hydroquinone from 0.3 M to 0.1 mM (correlation coefficient: 0.9965), 1.0 M to 0.3 mM (correlation coefficient = 0.9971) and 10.0 M to 1.0 mM (correlation coefficient = 0.9957) with the limit of detection was obtained at 0.83 nM, 0.43 M and 5.7 M, respectively. Interferences of several ions and compounds were studied and most of them did not interfere on the voltammetric responses. As a conclusion, the fabricated electrodes displayed excellent analytical performance with wider linear range, lower limit of detection and also exhibited good reproducibility, repeatability and stability. In its implication, these proposed electrodes were successfully applied for determination of acetaminophen, dopamine and hydroquinone in pharmaceutical tablet, dopamine hydrochloride injection, water samples and cosmetic cream, respectively. |
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