Development of fish scale-collagen cream (CoC) from water-in-virgin coconut oil emulsion medium for topical application

This study aimed to develop and characterise the fish scale-collagen cream (CoC) fortopical application. Hydrolysed collagen (HC) was extracted from Tilapia fish scales using acombination of hydrothermal extraction and enzymatic hydrolysis. This HC (molecular weight, Mw 1 kDa) was incorporated in wa...

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Main Author:	Hasnor Izzati Che Razali
Format:	thesis
Language:	eng
Published:	2019
Subjects:	QP Physiology
Online Access:	https://ir.upsi.edu.my/detailsg.php?det=5365
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institution	Universiti Pendidikan Sultan Idris
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language	eng
topic	QP Physiology
spellingShingle	QP Physiology Hasnor Izzati Che Razali Development of fish scale-collagen cream (CoC) from water-in-virgin coconut oil emulsion medium for topical application
description	This study aimed to develop and characterise the fish scale-collagen cream (CoC) fortopical application. Hydrolysed collagen (HC) was extracted from Tilapia fish scales using acombination of hydrothermal extraction and enzymatic hydrolysis. This HC (molecular weight, Mw 1 kDa) was incorporated in water-in-oil (w/o) emulsion of Span 60:Tween 60/water/virgin coconut oil(VCO) system at water volume fractions (w) of 0.74, 0.83, and 0.94 via high shear homogenisationtechnique. The developed CoC were then characterised by optical polarising microscope (OPM), fieldemission scanning electron microscopy (FESEM), particle size analyser, differential scanningcalorimetry (DSC), and rheometer. Up to 20 wt% HC has been successfully loaded in all emulsionsystems and the optimum loading achieved at HC content as low as 5 wt%. The best CoC systemwith great physical characteristic, fine texture (305 nm) and uniformly disperse in VCO phasewas produced by emulsion at the lowest w (0.94). The developed CoC has been foundto be thermally stable with Tc and Tm range between -20 to -30 ? and 10 to 20 ?,respectively. The rheological properties of CoC demonstrated shear thinning behaviour andthus greatly meet the needs of topical applications. The permeation study of ex vivorat skin showed that HC in emulsion droplets (CoC system) easily pass through theskin. Cytotoxicity study through in vitro fibroblast cells and in vivo toxicity to the miceshowed that HC at 25 and 50 mg/kg body weight did not give chronic toxic to the mice. Inconclusion, CoC from water-in-VCO emulsion system was succesfully developed. As an implication,the developed CoC is potentially used as a carrier for HC in topical application.
format	thesis
qualification_name
qualification_level	Doctorate
author	Hasnor Izzati Che Razali
author_facet	Hasnor Izzati Che Razali
author_sort	Hasnor Izzati Che Razali
title	Development of fish scale-collagen cream (CoC) from water-in-virgin coconut oil emulsion medium for topical application
title_short	Development of fish scale-collagen cream (CoC) from water-in-virgin coconut oil emulsion medium for topical application
title_full	Development of fish scale-collagen cream (CoC) from water-in-virgin coconut oil emulsion medium for topical application
title_fullStr	Development of fish scale-collagen cream (CoC) from water-in-virgin coconut oil emulsion medium for topical application
title_full_unstemmed	Development of fish scale-collagen cream (CoC) from water-in-virgin coconut oil emulsion medium for topical application
title_sort	development of fish scale-collagen cream (coc) from water-in-virgin coconut oil emulsion medium for topical application
granting_institution	Universiti Pendidikan Sultan Idris
granting_department	Fakulti Sains dan Matematik
publishDate	2019
url	https://ir.upsi.edu.my/detailsg.php?det=5365
_version_	1747833184254427136
spelling	oai:ir.upsi.edu.my:53652020-11-17 Development of fish scale-collagen cream (CoC) from water-in-virgin coconut oil emulsion medium for topical application 2019 Hasnor Izzati Che Razali QP Physiology This study aimed to develop and characterise the fish scale-collagen cream (CoC) fortopical application. Hydrolysed collagen (HC) was extracted from Tilapia fish scales using acombination of hydrothermal extraction and enzymatic hydrolysis. This HC (molecular weight, Mw 1 kDa) was incorporated in water-in-oil (w/o) emulsion of Span 60:Tween 60/water/virgin coconut oil(VCO) system at water volume fractions (w) of 0.74, 0.83, and 0.94 via high shear homogenisationtechnique. The developed CoC were then characterised by optical polarising microscope (OPM), fieldemission scanning electron microscopy (FESEM), particle size analyser, differential scanningcalorimetry (DSC), and rheometer. Up to 20 wt% HC has been successfully loaded in all emulsionsystems and the optimum loading achieved at HC content as low as 5 wt%. The best CoC systemwith great physical characteristic, fine texture (305 nm) and uniformly disperse in VCO phasewas produced by emulsion at the lowest w (0.94). The developed CoC has been foundto be thermally stable with Tc and Tm range between -20 to -30 ? and 10 to 20 ?,respectively. The rheological properties of CoC demonstrated shear thinning behaviour andthus greatly meet the needs of topical applications. The permeation study of ex vivorat skin showed that HC in emulsion droplets (CoC system) easily pass through theskin. Cytotoxicity study through in vitro fibroblast cells and in vivo toxicity to the miceshowed that HC at 25 and 50 mg/kg body weight did not give chronic toxic to the mice. Inconclusion, CoC from water-in-VCO emulsion system was succesfully developed. As an implication,the developed CoC is potentially used as a carrier for HC in topical application. 2019 thesis https://ir.upsi.edu.my/detailsg.php?det=5365 https://ir.upsi.edu.my/detailsg.php?det=5365 text eng closedAccess Doctoral Universiti Pendidikan Sultan Idris Fakulti Sains dan Matematik Agero, A. L., & Verallo-Rowell V. M. (2004). A randomized double-blind controlledtrial comparing extra virgin coconut oil with mineral oil as a moisturizer for mild to moderatexerosis. Dermatitis, 15(3), 109-16.Alberts, B., Bray, D., Hopkin, K., Johnson, A. D., Lewis, J., & Roberts, K. (2010).Essential Cell Biology (3rd ed., Chapter 20). New York: Garland Science.Alexander, A., Dwivedi, S., Ajazuddin, Giri, T.K., Saraf, S., Saraf, S., & Tripathi, D.K. (2012). Approaches for breaking the barriers of drug permeation through transdermaldrug delivery. Journal of Controlled Release, 164(1), 26-40.Almeida, P. F., Vanalle, R. M.. & Santana, J. C. C. (2012). 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