Aphrodisiac properties and toxicological evaluation of Aquilaria malaccensis and Aquilaria subintegra (Agarwood) leaves Aqueous extract in ICR Mice

This study aimed to investigate the properties of aphrodisiac and to evaluate thetoxicological effect of leaves aqueous extract from Aquilaria malaccensis (AEAM)and Aquilaria subintegra (AEAS) against ICR mice. The aphrodisiac properties,which include sexual behaviour, orientation activity, number o...

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Main Author:	Nur Hidayat Che Musa
Format:	thesis
Language:	eng
Published:	2019
Subjects:	QK Botany
Online Access:	https://ir.upsi.edu.my/detailsg.php?det=6427
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institution	Universiti Pendidikan Sultan Idris
collection	UPSI Digital Repository
language	eng
topic	QK Botany
spellingShingle	QK Botany Nur Hidayat Che Musa Aphrodisiac properties and toxicological evaluation of Aquilaria malaccensis and Aquilaria subintegra (Agarwood) leaves Aqueous extract in ICR Mice
description	This study aimed to investigate the properties of aphrodisiac and to evaluate thetoxicological effect of leaves aqueous extract from Aquilaria malaccensis (AEAM)and Aquilaria subintegra (AEAS) against ICR mice. The aphrodisiac properties,which include sexual behaviour, orientation activity, number of offspring, male tofemale ratio of offspring, the percentage of pregnancy and testosterone level.Meanwhile, toxicological evaluation consists of acute and sub-acute study. Inaphrodisiac study, the treated groups received 50, 100, 200, 500, and 1000 mg/kgbody weight (b.w.) of extracts for 21 consecutive days. In acute toxicity study, thetreated animals received a single dose at 2000 mg/kg b.w., while in sub-acute toxicitystudy, the treated groups received 50, 100, 150, 200, 500, and 1000 mg/kg b.w. ofextracts for 21 consecutive days compared to control groups that received normalsaline only. Statistical analyses were performed using t-test and one-way ANOVAand also considered significantly different at p0.05) in sexual behaviour and orientation activity of treated mice ascompared to the controls. The treatment groups that received higher doses (500 and1000 mg/kg) of both extracts found to be inactive due to the sedative effect. However,higher aphrodisiac properties were displayed by AEAM treated mice compared toAEAS. The number of offspring in AEAS was higher compared to AEAM.Toxicological evaluation showed that there was a significant increase (p
format	thesis
qualification_name
qualification_level	Doctorate
author	Nur Hidayat Che Musa
author_facet	Nur Hidayat Che Musa
author_sort	Nur Hidayat Che Musa
title	Aphrodisiac properties and toxicological evaluation of Aquilaria malaccensis and Aquilaria subintegra (Agarwood) leaves Aqueous extract in ICR Mice
title_short	Aphrodisiac properties and toxicological evaluation of Aquilaria malaccensis and Aquilaria subintegra (Agarwood) leaves Aqueous extract in ICR Mice
title_full	Aphrodisiac properties and toxicological evaluation of Aquilaria malaccensis and Aquilaria subintegra (Agarwood) leaves Aqueous extract in ICR Mice
title_fullStr	Aphrodisiac properties and toxicological evaluation of Aquilaria malaccensis and Aquilaria subintegra (Agarwood) leaves Aqueous extract in ICR Mice
title_full_unstemmed	Aphrodisiac properties and toxicological evaluation of Aquilaria malaccensis and Aquilaria subintegra (Agarwood) leaves Aqueous extract in ICR Mice
title_sort	aphrodisiac properties and toxicological evaluation of aquilaria malaccensis and aquilaria subintegra (agarwood) leaves aqueous extract in icr mice
granting_institution	Universiti Pendidikan Sultan Idris
granting_department	Fakulti Sains dan Matematik
publishDate	2019
url	https://ir.upsi.edu.my/detailsg.php?det=6427
_version_	1747833262893432832
spelling	oai:ir.upsi.edu.my:64272021-11-12 Aphrodisiac properties and toxicological evaluation of Aquilaria malaccensis and Aquilaria subintegra (Agarwood) leaves Aqueous extract in ICR Mice 2019 Nur Hidayat Che Musa QK Botany This study aimed to investigate the properties of aphrodisiac and to evaluate thetoxicological effect of leaves aqueous extract from Aquilaria malaccensis (AEAM)and Aquilaria subintegra (AEAS) against ICR mice. The aphrodisiac properties,which include sexual behaviour, orientation activity, number of offspring, male tofemale ratio of offspring, the percentage of pregnancy and testosterone level.Meanwhile, toxicological evaluation consists of acute and sub-acute study. Inaphrodisiac study, the treated groups received 50, 100, 200, 500, and 1000 mg/kgbody weight (b.w.) of extracts for 21 consecutive days. In acute toxicity study, thetreated animals received a single dose at 2000 mg/kg b.w., while in sub-acute toxicitystudy, the treated groups received 50, 100, 150, 200, 500, and 1000 mg/kg b.w. ofextracts for 21 consecutive days compared to control groups that received normalsaline only. Statistical analyses were performed using t-test and one-way ANOVAand also considered significantly different at p0.05) in sexual behaviour and orientation activity of treated mice ascompared to the controls. The treatment groups that received higher doses (500 and1000 mg/kg) of both extracts found to be inactive due to the sedative effect. However,higher aphrodisiac properties were displayed by AEAM treated mice compared toAEAS. The number of offspring in AEAS was higher compared to AEAM.Toxicological evaluation showed that there was a significant increase (p 2019 thesis https://ir.upsi.edu.my/detailsg.php?det=6427 https://ir.upsi.edu.my/detailsg.php?det=6427 text eng closedAccess Doctoral Universiti Pendidikan Sultan Idris Fakulti Sains dan Matematik Aattiyyah, A. A., Wan Afiqah Syahirah, W. G., Nor Azah, M. A., Kannan, T. P.,Suharni, M., & Ahmad, A. (2017). Phytochemical properties and traditional uses of selectedmedicinal plants in Malaysia: A review. Journal of Biomedical and Clinical Sciences, 2(2), 14-25.Abdillahi, H. S., & Van Staden, J. (2012). South African plants and male reproductive healthcare: Conception and contraception. Journal of Ethnopharmacology, 143(2), 475-480.Abedi, A., Parviz, M., Karimian, S. M., & Rodsari, H. R. S. (2013). Aphrodisiacactivity of aqueous extract of Phoenix dactylifera pollen in male rats. Advances in SexualMedicine, 3(01), 28-34.Achi, N. 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Aphrodisiac properties and toxicological evaluation of Aquilaria malaccensis and Aquilaria subintegra (Agarwood) leaves Aqueous extract in ICR Mice

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