Amphiphilic chitosan derivatives as environmental friendly media for water-insoluble pesticide formulations

This research aimed to synthesis and investigate the potential of amphiphilic chitosanderivatives, namely N-octyl-O-sulfate chitosan (NOOSC), N-octyl-N-succinylchitosan (NONSC), N-octyl-O-glycol chitosan (NOOGC), N-deoxycholic acid-Oglycolchitosan (DAGC), N-hexanoyl-O-glycol chitosan (HGC) and N-lau...

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Main Author:	Siti Najiah Mohd Yusoff
Format:	thesis
Language:	eng
Published:	2019
Subjects:	TP Chemical technology
Online Access:	https://ir.upsi.edu.my/detailsg.php?det=6430
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id	oai:ir.upsi.edu.my:6430
record_format	uketd_dc
institution	Universiti Pendidikan Sultan Idris
collection	UPSI Digital Repository
language	eng
topic	TP Chemical technology
spellingShingle	TP Chemical technology Siti Najiah Mohd Yusoff Amphiphilic chitosan derivatives as environmental friendly media for water-insoluble pesticide formulations
description	This research aimed to synthesis and investigate the potential of amphiphilic chitosanderivatives, namely N-octyl-O-sulfate chitosan (NOOSC), N-octyl-N-succinylchitosan (NONSC), N-octyl-O-glycol chitosan (NOOGC), N-deoxycholic acid-Oglycolchitosan (DAGC), N-hexanoyl-O-glycol chitosan (HGC) and N-lauryl-Oglycolchitosan (LGC) as environmental friendly media for atrazine, rotenone andthymol formulations. The amphiphilic chitosan derivatives were characterised usingproton nuclear magnetic resonance (1H NMR) spectrometer, Fourier transforminfrared (FTIR) spectrometer, CHNS-O elemental analyser, fluorescence spectrometerand scanning transmission electron microscope (STEM). Encapsulation efficiency ofpesticide active ingredients by amphiphilic chitosan derivatives was determined usinga high performance liquid chromatography (HPLC). The release mechanism ofatrazine, rotenone and thymol from the amphiphilic chitosan derivatives micelles wasfitted to four kinetic models. Pot experiments were carried out to monitor theeffectiveness of each pesticide formulation on weed (Cyperus kyllingia) and chilli(Capcisum annuum) plant infested by aphids, thrips and white fly. Research findingsfound that the amphiphilic chitosan derivatives have formed self-aggregates with aspherical shape. The critical micelles concentration (CMC) values of the amphiphilicchitosan derivatives were between 0.008 and 0.089 mg/mL. The encapsulationefficiency values for the amphiphilic chitosan were higher than 50%. All amphiphilicchitosan derivatives enhanced pesticides release performance as compared to purepesticides solution. The constant (n) values obtained from Korsmeyer-Peppas kineticmodel suggest that the release of pesticide active ingredients from the chitosanderivatives micelle was controlled by relaxation of polymer chains. Based on potexperiments, the amphiphilic chitosan derivatives formulation effectively treat thetarget species. In conclusion, the amphiphilic chitosan derivatives are potential ascarrier agents for pesticide active ingredients. In implication, the amphiphilic chitosanderivatives as environmental friendly media able to reduce the use of organic solventsin pesticide formulations more than 60%.
format	thesis
qualification_name
qualification_level	Doctorate
author	Siti Najiah Mohd Yusoff
author_facet	Siti Najiah Mohd Yusoff
author_sort	Siti Najiah Mohd Yusoff
title	Amphiphilic chitosan derivatives as environmental friendly media for water-insoluble pesticide formulations
title_short	Amphiphilic chitosan derivatives as environmental friendly media for water-insoluble pesticide formulations
title_full	Amphiphilic chitosan derivatives as environmental friendly media for water-insoluble pesticide formulations
title_fullStr	Amphiphilic chitosan derivatives as environmental friendly media for water-insoluble pesticide formulations
title_full_unstemmed	Amphiphilic chitosan derivatives as environmental friendly media for water-insoluble pesticide formulations
title_sort	amphiphilic chitosan derivatives as environmental friendly media for water-insoluble pesticide formulations
granting_institution	Universiti Pendidikan Sultan Idris
granting_department	Fakulti Sains dan Matematik
publishDate	2019
url	https://ir.upsi.edu.my/detailsg.php?det=6430
_version_	1747833263817228288
spelling	oai:ir.upsi.edu.my:64302021-11-15 Amphiphilic chitosan derivatives as environmental friendly media for water-insoluble pesticide formulations 2019 Siti Najiah Mohd Yusoff TP Chemical technology This research aimed to synthesis and investigate the potential of amphiphilic chitosanderivatives, namely N-octyl-O-sulfate chitosan (NOOSC), N-octyl-N-succinylchitosan (NONSC), N-octyl-O-glycol chitosan (NOOGC), N-deoxycholic acid-Oglycolchitosan (DAGC), N-hexanoyl-O-glycol chitosan (HGC) and N-lauryl-Oglycolchitosan (LGC) as environmental friendly media for atrazine, rotenone andthymol formulations. The amphiphilic chitosan derivatives were characterised usingproton nuclear magnetic resonance (1H NMR) spectrometer, Fourier transforminfrared (FTIR) spectrometer, CHNS-O elemental analyser, fluorescence spectrometerand scanning transmission electron microscope (STEM). Encapsulation efficiency ofpesticide active ingredients by amphiphilic chitosan derivatives was determined usinga high performance liquid chromatography (HPLC). The release mechanism ofatrazine, rotenone and thymol from the amphiphilic chitosan derivatives micelles wasfitted to four kinetic models. Pot experiments were carried out to monitor theeffectiveness of each pesticide formulation on weed (Cyperus kyllingia) and chilli(Capcisum annuum) plant infested by aphids, thrips and white fly. Research findingsfound that the amphiphilic chitosan derivatives have formed self-aggregates with aspherical shape. The critical micelles concentration (CMC) values of the amphiphilicchitosan derivatives were between 0.008 and 0.089 mg/mL. The encapsulationefficiency values for the amphiphilic chitosan were higher than 50%. All amphiphilicchitosan derivatives enhanced pesticides release performance as compared to purepesticides solution. The constant (n) values obtained from Korsmeyer-Peppas kineticmodel suggest that the release of pesticide active ingredients from the chitosanderivatives micelle was controlled by relaxation of polymer chains. Based on potexperiments, the amphiphilic chitosan derivatives formulation effectively treat thetarget species. In conclusion, the amphiphilic chitosan derivatives are potential ascarrier agents for pesticide active ingredients. In implication, the amphiphilic chitosanderivatives as environmental friendly media able to reduce the use of organic solventsin pesticide formulations more than 60%. 2019 thesis https://ir.upsi.edu.my/detailsg.php?det=6430 https://ir.upsi.edu.my/detailsg.php?det=6430 text eng closedAccess Doctoral Universiti Pendidikan Sultan Idris Fakulti Sains dan Matematik Abigail M, E. A., Samuel S, M., & Chidambaram, R. (2016). Application of rice husknanosorbents containing 2,4-dichlorophenoxyacetic acid herbicide to control weeds andreduce leaching from soil. 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Chemistry Central Journal, 7, 39.LIST OF PUBLICATIONS1. Yusoff, S. N. M., Kamari, A., & Aljafree, N. F. A. (2016). A review of materialsused as carrier agents in pesticide formulation. International Journal ofEnvironmental Science and Technology, 13, 2977-2994.2. Yusoff, S. N. M., & Kamari, A. (2018). N-deoxycholic acid-O-glycol chitosan as a potentialcarrier agent for botanical pesticide rotenone. Journal of Applied Polymer Science, 135,46855.3. Yusoff, S. N. M., Kamari, A., Ishak, S., & Halim, A. L. A. (2018). N-hexanoyl- O-glycolchitosan as a carrier agent for water-insoluble herbicide. Journal of Physics: ConferencesSeries, 1097, 012053.4. Kamari, A. & Yusoff, S. N. M. (2019). N-octyl chitosan derivatives asamphiphilic carrier agents for herbicide formulations. Open Chemistry, 17, 365-380.LIST OF CONFERENCES1. International Conference on Research, Implementation and Education ofMathematics and Science 2016 (ICRIEMS 2016). Universitas Negeri Yogyakarta.May 2016. Oral Presentation. Synthesis and characterisation of an amphiphilic chitosan derivativeas a carrier agent for rotenone.2. International Postgraduate Conference on Science and Mathematics 2017 (IPCSM 2017). Universiti Pendidikan Sultan Idris. October 2017. Oral Presentation.Synthesis and characterisation of N-octyl-N-succinyl chitosan as a new carrier agent for rotenonepesticide.3. International Conference on Research, Implementation and Education ofMathematics and Science 2018 (ICRIEMS 2018). Universitas Negeri Yogyakarta.May 2016. Oral Presentation. N-hexanoyl-O-glycol chitosan as a carrier agent forwater-insoluble herbicide.4. International Conference on Research, Implementation and Education ofMathematics and Science 2019 (ICRIEMS 2019). Universitas Negeri Yogyakarta.July 2019. Oral Presentation. Synthesis and characterisation of thymol-loaded lauryl glycolchitosan for pesticide formulation.5. The Science and Science Education International Seminar (SSEIS) 2019.Universitas Negeri Yogyakarta. September 2019. Oral Presentation. Alkylglycol chitosan derivatives for encapsulation and controlled release of rotenone.

Amphiphilic chitosan derivatives as environmental friendly media for water-insoluble pesticide formulations

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