Anti-diabetic effect of agarwood leaf extracts on straptozotocin-induced type II diabetic ICR mice
Alternative treatments of insulin-independent diabetes mellitus have attracted many researchersover the years. The treatment should have a clearer mechanism of action and easier to administer.Asian traditional medicine contains a number of herbal extracts believed to combat thesymptoms of diabetes m...
Saved in:
| Main Author: | |
|---|---|
| Format: | thesis |
| Language: | eng |
| Published: |
2019
|
| Subjects: | |
| Online Access: | https://ir.upsi.edu.my/detailsg.php?det=6552 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | Alternative treatments of insulin-independent diabetes mellitus have attracted many researchersover the years. The treatment should have a clearer mechanism of action and easier to administer.Asian traditional medicine contains a number of herbal extracts believed to combat thesymptoms of diabetes mellitus. Thus, the purpose of this study was to investigate the potentialof agarwood leaf extracts against type II diabetic ICR mice. A group of ICR mice of both sexes,aged 8 weeks were induced by a single intraperitoneal injection of 100 mg/kg body weight ofstreptozotocin (STZ). Mice (fasting) with blood glucose over 200 mg/dl were used in thisexperiment. Diabetic mice were divided into three groups and were forced fed with 50, 100 and150 mg plant extract /kg body weight for 14 consecutive days respectivly. Two different typesof solvents used in this study were distilled water and 95% methanol. Aqueous and methanolicextracts of Aquilaria malaccensis leaf exhibited a significant reduction of hyperglycemia infasting diabetic mice at the lowest concentration (50 mg/kg b.w). Both extracts with differentsolvents reduced hyperglycemia within three days of administration and these were observed forall doses. For methanolic extract, low (50 mg/kg body weight) and moderate (100 mg/kg bodyweight) doses, reduced hyperglycemia in fasting diabetic mice compered with the highest dose(150 mg/kg body weight) after two hours of forced fed. In conclusion, these data suggest thatboth extracts of agarwood leaf possess potential anti-diabetic activity in both diabetic male andfemale mice. Hence, active constituents of agarwood leaf extracts which responsible for antidiabeticactivity requires further to be investigated and these findings contribute to potentialdiabetic treatment. |
|---|