Analysis of essential oils and phytochemicals from selected annonaceae and cyclooxygenase-2 inhibitory activity
The aims of this study were to analyse the essential oils, phytochemistry andcyclooxygenase-2 inhibitory activity of selected species of the genus Polyalthia (P.stenopetalla, P. sumatrana, P. cauliflora and P. rumphii), Xylopia (X. magna, X.ferruginea and X. frutescens) and Goniothalamus (G. macroph...
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| Format: | thesis |
| Language: | eng |
| Published: |
2021
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| Subjects: | |
| Online Access: | https://ir.upsi.edu.my/detailsg.php?det=6698 |
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| Summary: | The aims of this study were to analyse the essential oils, phytochemistry andcyclooxygenase-2 inhibitory activity of selected species of the genus Polyalthia (P.stenopetalla, P. sumatrana, P. cauliflora and P. rumphii), Xylopia (X. magna, X.ferruginea and X. frutescens) and Goniothalamus (G. macrophyllus and G.malayanus) from Annonaceae family. The essential oils were obtained viahydrodistillation technique and their chemical compositions were determined by gas chromatography(GC-FID) and gas chromatography-mass spectrometry (GC-MS). The phytochemicals were obtained using chromatography techniques and their structures were confirmed byspectroscopic data and comparison with literatures. The bioactivity of the essential oils andextracts was investigated using cyclooxygenase-2 (COX-2) inhibitory activity. The study showed theessential oils of P. sumatrana, P. stenopetalla, P. cauliflora and P. rumphii were made upof bicyclogermacrene (18.8%), -cadinol (13.0%), -elemene (38.1%) and germacrene D(33.3%), respectively. The major components of essential oil from X. frutescenswas bicyclogermacrene (22.8%), whereas X. magna gave germacrene D (35.9%) and X.ferruginea was dominated by bicyclogermacrene (23.6%). As for G. malayanus andG. macrophyllus, the essential oils consisted mainly of bicyclogermacrene (43.9%) andgermacrene D (25.1%), respectively. The dichloromethane and methanol leaf extracts of P. rumphii yielded seven phytochemicals identified as 5,7- dimethoxyflavone, 4?,5,7-trimethoxyflavone, 5-hydroxy-7-methoxyflavone, 4?- hydroxy-5,7-dimethoxyflavone,-sitosterol, lupeol and taraxerol. The essential oil ofG. macrophyllus and methanolic extracts of X. magna and X. frutescens displayed the best results inCOX-2 inhibitory activity with percentage of 18.6%, 13.8% and 21.9%, respectively. In conclusion,the composition of the essential oils from nine species of Annonaceae family have shown thatsesquiterpene hydrocarbons as their major components, meanwhile phytochemical studies hadyielded flavonoids and terpenes compounds. The implication of this study demonstrate theessential oils and extractsof the genus Xylopia and Goniothalamus can be useful for rheumatism treatment. |
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