Isolation of chemical constituents from Alphonsea sp and their in silico xanthine oxidase inhibitory activities

Isolation of chemical constituents from Alphonsea sp and their in silico xanthine oxidase inhibitory activities

<p>The aim of this study was to identify the chemical constituents from two species</p><p>of Alphonsea sp., which were Alphonsea cylindrica and Alphonsea elliptica and</p><p>their in silico xanthine oxidase inhibitory activities....

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Main Author: M. Nur Sidik
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Language:eng
Published: 2022
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QD Chemistry
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institution Universiti Pendidikan Sultan Idris
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topic QD Chemistry
spellingShingle QD Chemistry
M. Nur Sidik
Isolation of chemical constituents from Alphonsea sp and their in silico xanthine oxidase inhibitory activities
description <p>The aim of this study was to identify the chemical constituents from two species</p><p>of Alphonsea sp., which were Alphonsea cylindrica and Alphonsea elliptica and</p><p>their in silico xanthine oxidase inhibitory activities. The samples were dried, then</p><p>extracted sequentially using hexane, dichloromethane, and methanol. Chemical</p><p>constituents were isolated and purified through chromatographic techniques. The</p><p>structure of the compounds were elucidated through spectroscopic data and</p><p>comparison with literature. In silico based on molecular docking using YASARA</p><p>program was carried out to study the inhibition mechanism and interactions of</p><p>compounds against xanthine oxidase. Six chemical constituents were isolated;</p><p>stigmasterol, atherospermidine, kinabaline, muniranine, methyl 4-hydroxy-3,5-</p><p>dimethoxybenzoate and 3- hydroxy-4-methoxy-benzoic acid. Both methyl 4-</p><p>hydroxy-3,5-dimethoxybenzoate and 3- hydroxy-4-methoxy-benzoic acid were</p><p>firstly reported from Alphonsea sp. The results of the molecular docking study</p><p>revealed that atherospermidine bind to active sites located in the FAD domain of</p><p>xanthine oxidase which suggest it is a competitive inhibitor. Meanwhile, other</p><p>compounds isolated are non-competitive inhibitors. In conclusion, six chemical</p><p>compounds were isolated from Alphonsea sp and all interactions of the</p><p>compounds with xanthine oxidase in silico were investigated. The findings of this</p><p>study reveal the potential of Alphonsea sp. as remedy for gout.</p>
format thesis
qualification_name
qualification_level Master's degree
author M. Nur Sidik
author_facet M. Nur Sidik
author_sort M. Nur Sidik
title Isolation of chemical constituents from Alphonsea sp and their in silico xanthine oxidase inhibitory activities
title_short Isolation of chemical constituents from Alphonsea sp and their in silico xanthine oxidase inhibitory activities
title_full Isolation of chemical constituents from Alphonsea sp and their in silico xanthine oxidase inhibitory activities
title_fullStr Isolation of chemical constituents from Alphonsea sp and their in silico xanthine oxidase inhibitory activities
title_full_unstemmed Isolation of chemical constituents from Alphonsea sp and their in silico xanthine oxidase inhibitory activities
title_sort isolation of chemical constituents from alphonsea sp and their in silico xanthine oxidase inhibitory activities
granting_institution Universiti Pendidikan Sultan Idris
granting_department Fakulti Sains dan Matematik
publishDate 2022
url https://ir.upsi.edu.my/detailsg.php?det=9289
_version_ 1776104613375639552
spelling oai:ir.upsi.edu.my:92892023-08-08 Isolation of chemical constituents from Alphonsea sp and their in silico xanthine oxidase inhibitory activities 2022 M. Nur Sidik QD Chemistry <p>The aim of this study was to identify the chemical constituents from two species</p><p>of Alphonsea sp., which were Alphonsea cylindrica and Alphonsea elliptica and</p><p>their in silico xanthine oxidase inhibitory activities. The samples were dried, then</p><p>extracted sequentially using hexane, dichloromethane, and methanol. Chemical</p><p>constituents were isolated and purified through chromatographic techniques. The</p><p>structure of the compounds were elucidated through spectroscopic data and</p><p>comparison with literature. In silico based on molecular docking using YASARA</p><p>program was carried out to study the inhibition mechanism and interactions of</p><p>compounds against xanthine oxidase. Six chemical constituents were isolated;</p><p>stigmasterol, atherospermidine, kinabaline, muniranine, methyl 4-hydroxy-3,5-</p><p>dimethoxybenzoate and 3- hydroxy-4-methoxy-benzoic acid. Both methyl 4-</p><p>hydroxy-3,5-dimethoxybenzoate and 3- hydroxy-4-methoxy-benzoic acid were</p><p>firstly reported from Alphonsea sp. The results of the molecular docking study</p><p>revealed that atherospermidine bind to active sites located in the FAD domain of</p><p>xanthine oxidase which suggest it is a competitive inhibitor. Meanwhile, other</p><p>compounds isolated are non-competitive inhibitors. In conclusion, six chemical</p><p>compounds were isolated from Alphonsea sp and all interactions of the</p><p>compounds with xanthine oxidase in silico were investigated. The findings of this</p><p>study reveal the potential of Alphonsea sp. as remedy for gout.</p> 2022 thesis https://ir.upsi.edu.my/detailsg.php?det=9289 https://ir.upsi.edu.my/detailsg.php?det=9289 text eng closedAccess Masters Universiti Pendidikan Sultan Idris Fakulti Sains dan Matematik <p>Abdul Hafiz, F., Mohammed, A., Kayat, F., Bhaskar, M., Hamzah, Z., Podapati, S. K. & Reddy, L.V. (2020). Xanthine oxidase inhibitory activity, chemical composition, antioxidant properties and GC-MS analysis of keladi cantik (Alocasia longiloba Miq). Molecules, 25, 2658.</p><p>Abdul Latieff Mohamad (2015). The country's biodiversity policy is a highlight.Journal of Salam Lestari. Institute for Environment and Development. 35, 1-9.</p><p>Abdul Rauf & Noor Jehan. (2017). Natural products as a potential enzyme inhibitors from medicinal plants. Book IntechOpen. 165-177.</p><p>Afroz, M., Zihad, S. M. N. K., Uddin, S. J., Rouf, R., Rahman, M. S., Islam, M. T. & Sarker, S. D. (2019). 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