Development, characterisation and translocation of valproic acid-encapsulated nanoemulsion across blood-brain barrier

Valproic acid (VPA) is a widely used antiepileptic drug (AED) for epilepsy especially in generalized and absence seizures. However, VPA has high plasma protein binding (90 % - 95 %) so only low amount of free VPA were able to reach the brain. An increase in therapeutic dose is not feasible as it wil...

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Bibliographic Details
Main Author: Tan, Suk Fei
Format: Thesis
Published: 2017
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