Kinetics And Modelling For The Production Of (S)-Ibuprofen Acid
The effect of co-solvents and bases have been investigated in Candida rugosa lipase (CRL)-catalyzed hydrolysis of (R,S)-2-ethoxyethyl ibuprofen ester in biphasic water-isooctane medium. A high log P and low pKa values of co-solvent has reduced the reaction rate for the production of (S)-ibuprofen ac...
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| التنسيق: | أطروحة |
| اللغة: | English |
| منشور في: |
2012
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| الوصول للمادة أونلاين: | http://eprints.usm.my/44801/1/FADZIL%20NOOR%20BIN%20GONAWAN.pdf |
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my-usm-ep.448012019-07-02T01:19:25Z Kinetics And Modelling For The Production Of (S)-Ibuprofen Acid 2012-06 Gonawan, Fadzil Noor TP1-1185 Chemical technology The effect of co-solvents and bases have been investigated in Candida rugosa lipase (CRL)-catalyzed hydrolysis of (R,S)-2-ethoxyethyl ibuprofen ester in biphasic water-isooctane medium. A high log P and low pKa values of co-solvent has reduced the reaction rate for the production of (S)-ibuprofen acid. Moreover, the hydrolysis process shows an optimum performance at only 2% (v/v) dimethyl sulfoxide (DMSO) and at the reaction temperature of 30°C. The addition of 2% (v/v) DMSO has increased the conversion of substrate and further increase in the concentration of DMSO has resulted in a low initial reaction rate and conversion of substrate, however gives a high enantiomeric excess of the product (eeP). 2012-06 Thesis http://eprints.usm.my/44801/ http://eprints.usm.my/44801/1/FADZIL%20NOOR%20BIN%20GONAWAN.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Kejuteraan Kimia |
| institution |
Universiti Sains Malaysia |
| collection |
USM Institutional Repository |
| language |
English |
| topic |
TP1-1185 Chemical technology |
| spellingShingle |
TP1-1185 Chemical technology Gonawan, Fadzil Noor Kinetics And Modelling For The Production Of (S)-Ibuprofen Acid |
| description |
The effect of co-solvents and bases have been investigated in Candida rugosa lipase (CRL)-catalyzed hydrolysis of (R,S)-2-ethoxyethyl ibuprofen ester in biphasic water-isooctane medium. A high log P and low pKa values of co-solvent has reduced the reaction rate for the production of (S)-ibuprofen acid. Moreover, the hydrolysis process shows an optimum performance at only 2% (v/v) dimethyl sulfoxide (DMSO) and at the reaction temperature of 30°C. The addition of 2% (v/v) DMSO has increased the conversion of substrate and further increase in the concentration of DMSO has resulted in a low initial reaction rate and conversion of substrate, however gives a high enantiomeric excess of the product (eeP). |
| format |
Thesis |
| qualification_level |
Master's degree |
| author |
Gonawan, Fadzil Noor |
| author_facet |
Gonawan, Fadzil Noor |
| author_sort |
Gonawan, Fadzil Noor |
| title |
Kinetics And Modelling For The Production Of (S)-Ibuprofen Acid |
| title_short |
Kinetics And Modelling For The Production Of (S)-Ibuprofen Acid |
| title_full |
Kinetics And Modelling For The Production Of (S)-Ibuprofen Acid |
| title_fullStr |
Kinetics And Modelling For The Production Of (S)-Ibuprofen Acid |
| title_full_unstemmed |
Kinetics And Modelling For The Production Of (S)-Ibuprofen Acid |
| title_sort |
kinetics and modelling for the production of (s)-ibuprofen acid |
| granting_institution |
Universiti Sains Malaysia |
| granting_department |
Pusat Pengajian Kejuteraan Kimia |
| publishDate |
2012 |
| url |
http://eprints.usm.my/44801/1/FADZIL%20NOOR%20BIN%20GONAWAN.pdf |
| _version_ |
1747821401971097600 |